The Effect of Adjuvant Ozone Therapy in Nonsurgical Periodontal Treatment: A Systematic Review with Meta-analysis

Authors: Daniela Pafiadache Thomé, Francisco Wilker Mustafa Gomes Muniz, Alessandra Cardoso Nicolini, Cassiano Kuchenbecker Rösing and Juliano Cavagni

Abstract

Aims: To evaluate the efficacy of ozone therapy as an adjunct to non-surgical periodontal therapy. Materials and methods: Randomized clinical trials that used any form of ozone therapy as adjuvant to nonsurgical periodontal therapy were included. MEDLINE-PubMed, Embase and Scopus databases were searched to identify these studies. Three different meta-analyses were conducted for reduction of probing pocket depth (PPD), clinical attachment (CAL) gain and reduction of bleeding on probing (BoP). Results: Thirteen studies were included, which utilized ozonated water, ozonated gas, ozonated olive oil and nano-bubble water. Groups that used adjunct ozone therapy demonstrated significantly higher CAL gain when compared to individuals that received scaling and root planing (SRP) alone or in association with placebo (Mean difference [MD]: -0.32; 95% Confidence interval [95%CI]: -0.52 – -0.11). Regarding PPD reduction, a significantly greater reduction was also observed in groups that used ozone therapy in comparison to control groups (MD: -0.41; 95%CI: -0.71– -0.11). However, no statistically significant differences between ozone therapy and controls were found for BoP (MD: -6.49; 95%CI: -18.74–5.75). Conclusions: It was concluded that ozone therapy when used as an adjuvant to nonsurgical periodontal therapy may provide modest additional gain in CAL and higher reduction in PPD.

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