July 2021
Gingival tissue heat shock protein expression in aggressive and chronic periodontitis
Abstract
Aims: The purpose of the study was to examine the gingival tissue mRNA and protein expression of heat shock protein (HSP) 60 and HSP70 in generalized chronic periodontitis (GCP), generalized aggressive periodontitis (G-AgP) and individuals with periodontal health (PH). Materials and methods: Gingival tissue biopsies were acquired from 39 patients with G-CP (n=39), G-AgP (n=37) and PH (n=15). Localization and mRNA expression of HSP60 and HSP70 were evaluated by immunohistochemistry and quantitative real-time PCR. Probing depth (PD), clinical attachment level (CAL), plaque index (PI) and bleeding on probing (BOP) were assessed. Non-parametric statistical methods were used. Results: The mRNA expression of HSP60 was significantly higher in the G-AgP (1.7-fold, P<0.001) and G-CP (2.5-fold, P<0.001) than the PH group. The mRNA expression of HSP60 was positively correlated with the CAL, PI and BOP. HSP70 mRNA expression did not significantly differ among the study groups (P>0.05). In gingival tissues of G-CP and G-AgP strong positive staining of HSP60 and HSP70 was observed both in the epithelium and lamina propria. Conclusion: The higher mRNA expression of HSP60 in both aggressive and chronic periodontitis points a relationship of this molecule with the pathogenesis of periodontitis. HSP70 mRNA expression levels did not show any contribution to periodontal disease.
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