April 2022

Aim: To investigate self-reported short-term morbidity after the application of advanced platelet rich fibrin (A-PRF+) in combination with periodontal regenerative microsurgery in molar furcations and compare this the use of enamel matrix derivative application (EMD) or open flap debridement (OFD, control). Materials and Methods: A prospective randomized controlled trial was designed to study effects of A-PRF+, EMD or control for pocket closure of molar furcations grade II. Patients were randomly allocated in one of three treatment groups: OFD with application of A-PRF+, OFD with application of EMD and OFD alone. In all patients, venous blood was drawn from the antecubital fossa. A minimally invasive microsurgical approach was performed in all groups. Morbidity and patient-reported outcomes (PROs) were assessed by questionnaires up to 6 weeks postoperatively. Results: 15 patients (n=5 per treatment allocation) completed the six-week follow-up. No differences in pain medications and PROs were observed between the groups, except that patients in EMD group scored statistically significant higher for postoperative morbidity compared to OFD group during the first week. All the patients except one reported to undergo the treatment again. Conclusion: The use of A-PRF+ was not associated with a different post-operative pain and discomfort compared to EMD or OFD.