July 2010

The aim of this presentation is to review the literature concerning the link between drugs called bisphosphonates and the development of a condition called osteonecrosis of the jaws. The bisphosphonates are stable synthetic inorganic pyrophosphate analog drugs that have a high affinity for calcium and are used to treat patients with a variety of pathologies such as cancer and osteoporosis. Some reports linked them as a factor in the development of a condition called bisphosphonate-related osteonecrosis of the jaws, which has presented mostly in patients receiving the drug intravenously. However, oral administration of the drug presents itself as low-risk. This review suggests that any patient who plans to be treated with bisphosphonates should consult a dentist to ensure adequate oral health before treatment is indicated, especially if high doses by an intravenous route are prescribed, to avoid or reduce the need for any dental treatment while the patient is taking the drug and thereby prevent this pathology.